Selected Publications

Corcoran E, LeBlanc C, Huang YC, Arias Tsang M, Sarkiss A, Hu Y, Pedmale UV, Jacob Y (2022). Systematic histone H4 replacement in Arabidopsis thaliana reveals a role for H4R17 in regulating flowering time. Plant Cell [Pubmed]

Dubos T, Poulet A, Thomson G, Pery E, Chausse F, Tatout C, Desset S, van Wolfswinkel, JC, Jacob Y (2022) NODeJ: an ImageJ plugin for 3D segmentation of nuclear objects. BMC Bioinformatics 23 (1): 216 [Pubmed]

Davarinejad H, Huang Y-C, Mermaz B, LeBlanc C, Poulet A, Thomson G, Joly V, Munoz M, Arvanitis-Vigneault A, Valsakumar D, Villarino G,  Ross A, Rotstein BH, Alarcon EI, Voigt P, Dong J, Couture J-F, Jacob Y (2022). The H3.1 variant regulates TONSOKU-mediated DNA repair during replication. Science 375 (6586): 1281-1286. [Pubmed]

Dong J, LeBlanc C, Poulet A, Mermaz B, Villarino G, Webb KM, Joly V, Mendez J, Brunzelle JS, Dong, J, Voigt P, Jacob Y. (2021) H3.1K27me1 maintains transcriptional silencing and genome stability by preventing GCN5-mediated histone acetylation. Plant Cell 33(4):961-979. [Pubmed]

LeBlanc C, Zhang F, Mendez J, Lozano Y, Chatpar K, Irish VF, Jacob Y. (2018) Increased efficiency of targeted mutagenesis by CRISPR/Cas9 in plants using heat stress. Plant J. 93(2): 377-386. [Pubmed]

Jacob Y and Voight P. (2018) In Vitro assays to measure histone methyltransferase activity using different chromatin substrates. Methods Mol Biol 1675:345-360. [Pubmed]

Zhang F, LeBlanc C, Irish VF, Jacob Y. (2017) Rapid and efficient CRISPR/Cas9 gene editing in Critrus using the YAO promoter. Plant Cell Rep 12, 1883-1887. [Pubmed]

Jacob Y, Bergamin E, Donoghue MT, Mongeon B, LeBlanc C, Voigt P, Underwood CJ, Brunzelle JS, Michaels SD, Reinberg D, Couture JF, Martienssen RA. (2014) Selective methylation of histone H3 variant H3.1 regulates heterochromatin replication. Science 343(6176):1249-53.[Pubmed]

Jacob, Y., Stroud, H., Leblanc, C., Feng, S., Zhuo, L., Caro, E., Hassel, C., Gutierrez, C., Michaels, S.D., and Jacobsen, S.E. (2010) Regulation of heterochromatic DNA replication by histone H3 lysine 27 methyltransferases. Nature 466, 987-991. [Pubmed]

Jacob, Y., and Michaels, S.D. (2009) H3K27me1 is E(z) in animals, but not in plants. Epigenetics 4, 366-369. [Pubmed]

Jacob, Y., Feng, S., LeBlanc, C.A., Bernatavichute, Y.V., Stroud, H., Cokus, S., Johnson, L.M., Pellegrini, M., Jacobsen, S.E., and Michaels, S.D. (2009) ATXR5 and ATXR6 are H3K27 monomethyltransferases required for chromatin structure and gene silencing. Nature Structural and Molecular Biology 16, 763-768. [Pubmed]